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VOICE OVER: Lisa Yang
Script written by Q.V Hough

Grey's Anatomy is still going strong, and over the years there have been several well known celebrities that have appeared on the show. Granted, this is before they made it big! Did you catch Dylan Minnette, Mandy Moore, Abigail Breslin, Liza Weil, Sarah Paulson, Elisabeth Moss, Theo Rossi, KeKe Palmer, and Seth Green on the show?

#10: Seth Green

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So, you may recognize this guy from the original “It,” “Buffy the Vampire Slayer” or perhaps as Scott Evil from the “Austin Powers” franchise. Seth Green is also the creator of Adult Swim’s “Robot Chicken,” along with being the show’s featured voice. Back in 2007, he appeared on “Grey’s Anatomy” as Nick Hanscom, a patient with a tumor on his carotid artery. Spoiler Alert: it doesn’t go well for Nick. Just ask Lexie Grey, who is at the receiving end of an unfortunate blood burst. After the blown artery and a stroke, Nick Hanscom passes away, marking the end of Seth’s narrative arc.

#9: Keke Palmer

For her lead role on Nickelodeon’s “True Jackson, VP,” this starlet was one of TV’s most well-paid teenage actresses. Later on, Keke Palmer starred on the FOX series “Scream Queens.” One year before her first episode as Zayday Williams, Keke briefly appeared on “Grey’s Anatomy” as Sheryll Jeffries, a 17-year old patient with hypoplastic left heart syndrome. When surgery doesn’t work, Sheryll takes off and gets pregnant, which gives her a new perspective. She hopes to become a candidate for Cristina’s clinical trial, but unfortunately, she’s past the age cut-off and gets rejected.

#8: Theo Rossi

Some call him Juice, while other know him as Shades. Over the years, Theo Rossi has earned a loyal fanbase for his “Sons of Anarchy” and “Luke Cage” roles. For his two-episode run on “Grey’s Anatomy,” Theo plays a paramedic named Stan Giamatti, the unfortunate victim of an ambulance crash. The character actually gets wedged in a door but survives long enough to reunite with his wife. But just as Seth Green’s character passes away in the episode “Crash Into Me, Part 2,” poor Stan also has the same fate.

#7: Elisabeth Moss

Let’s be honest: most people know this actress as Peggy Olson from “Mad Men”. Elisabeth Moss also delivered award-winning performances in “Top of the Lake” and “The Handmaid’s Tale.” During “Grey’s Anatomy” Season 3, she appeared in one episode as Nina Rogerson, the daughter of a 41-year-old patient with a rare bone disease. The episode aired just four months before “Mad Men” premiered, so Moss was still relatively unknown. The character’s mother passes away, and Nina obviously has a rough time. This role essentially marks the rebirth of Elisabeth’s extraordinary television career.

#6: Sarah Paulson

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Marcia, Marcia, Marcia! This prolific actress famously starred as Marcia Clark on “The People v. O.J. Simpson,” and she’s also an “American Horror Story” regular. Though Paulson only appeared in one “Grey’s Anatomy” episode, the role is significant. She plays Meredith’s mother, Dr. Ellis Grey, who suffers from Alzheimer’s disease. The character shows up in a flashback sequence, as Richard Webber reflects on his former colleague. The episode examines the rise of AIDS in the early ‘80s, along with the relationship between two doctors who are trying to understand each other, and the nature of a frightening disease originally known as GRID.

#5: Liza Weil

Hey, isn’t that Paris Geller from “Gilmore Girls” and Bonnie Winterbottom from “How to Get Away with Murder”? Why, yes, yes it is. In a Season 5 episode of “Grey’s Anatomy,” Liza Weil plays Alison Clark, a Stage 4 cancer patient, who forms a bond with Izzie Stevens during chemotherapy treatment. The character ultimately passes away, and Alison’s moving performance opened the door for other roles. By the way, her “Gilmore Girls” co-star Edward Herrman appeared in three episodes from “Grey’s Anatomy” Season 4, playing the World’s Oldest Intern.

#4: Abigail Breslin

When only five years old, this actress starred in M. Night Shyamalan’s “Signs.” A few years later, Abigail Breslin received an Oscar nomination for “Little Miss Sunshine.” In recent years, she’s transitioned to the small screen as Libby on“Scream Queens.” Nearly a decade before, Abigail appeared in one “Grey’s Anatomy” episode as Megan Clover, aka Supergirl, a kid who does not feel pain whatsoever. It’s revealed that Megan suffers from internal injuries and CIPA (congenital insensitivity to pain with anhidrosis), which requires a corrective surgery. Overall, it’s an emotional performance that allows Abigail to be tough and vulnerable, as she learns just how much her foster parents truly care.

#3: Mandy Moore

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Since releasing her breakout single “Candy” in 1999, this versatile performer has established herself in both feature films and television. Back in 2010, Mandy Moore appeared in four “Grey’s Anatomy” episodes as Mary Portman, who initially needs a colostomy bag reversal surgery. Unfortunately for the character, a shooter emerges at the hospital; yet Mary survives and is reunited with husband Bill. Despite a successful surgery in Season 7, Mandy’s character slips into a coma and never wakes up, leaving her loved one to make a heart-breaking decision.

#2. Dylan Minnette

Before appearing in films like “Prisoners” and “Don’t Breathe,” this actor appeared in some of the most celebrated TV shows of the 2000s. Currently best known for his role as Clay Jensen on “13 Reasons Why”, Dylan Minnette once appeared as a guest star on Grey’s in its first season. He plays Ryan – a character with no official last name. However, the character is probably best known for not having external ears. In this storyline, Ryan bonds with Meredith while trick or treating, ultimately leading to a pro bono ear reconstruction.


Kyle Chandler

#1: Demi Lovato

She’s a movie star, a pop star and a television star. Believe it or not, it all began with a role on “Barney and Friends.” And just as Demi Lovato’s adult career reached new heights in 2010, she appeared on a Season 6 “Grey’s Anatomy” episode as Hayley May. The character has a rough time at Seattle Grace, as she is incorrectly diagnosed with paranoid schizophrenia. This role allows Demi to show off her acting chops; and the character arc has a happy ending, as Hayley is finally correctly diagnosed with Superior Canal Dehiscence Syndrome and undergoes successful surgery.

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